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Optic disc morphology in myopic primary open-angle glaucoma

J B Jonas1, A Dichtl

  • 1Universitäts-Augenklinik, Erlangen, Germany. Jost.Jonas@augen.med.uni-erlangen.de

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|November 14, 1997
PubMed
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[Not Available].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·2014

Highly myopic eyes with primary open-angle glaucoma exhibit distinct optic disc morphology, including larger, elongated discs and shallower cupping compared to less myopic eyes. This suggests a more diffuse pattern of glaucomatous optic nerve damage in these patients.

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Myopia Studies

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
  • High myopia is an increasingly prevalent condition associated with various ocular pathologies.
  • Optic disc morphology assessment is crucial for diagnosing and monitoring glaucoma progression.

Purpose of the Study:

  • To investigate and compare the optic disc morphology in highly myopic eyes (>-8 diopters) versus eyes with lower myopia (< -8 diopters) within the context of POAG.
  • To identify specific morphological differences that may influence glaucoma diagnosis and management in highly myopic individuals.

Main Methods:

  • Morphometric analysis of color stereo optic disc photographs.
  • Comparison between a cohort of 44 highly myopic POAG patients and 571 POAG patients with less myopic refractive errors.

Related Experiment Videos

  • Statistical analysis to determine significant differences in disc parameters.

    • Main Results:

    • Highly myopic eyes presented significantly larger optic discs (P < 0.0001).
    • Disc shape was significantly more elongated (P < 0.0005) and optic cup depth significantly shallower (P < 0.0001) in highly myopic eyes.
    • Concentric neuroretinal rim loss and reduced frequency of localized retinal nerve fiber layer defects were observed in the highly myopic group.
    • Zone beta of parapapillary atrophy was significantly larger in highly myopic eyes (P < 0.0001).

    Conclusions:

    • Optic disc morphology in POAG significantly differs between highly myopic eyes and those with hyperopia or lower myopia.
    • Highly myopic eyes with POAG are characterized by secondary macro-discs, elongated shape, shallow/concentric cupping, and large parapapillary atrophy.
    • Glaucomatous optic nerve damage in high myopia tends to be more diffuse than localized compared to normal refractive error eyes.