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Related Experiment Videos

n-3 fatty acids do not decrease plasma endothelin levels in healthy individuals

M S Christensen1, K Therkelsen, J M Møller

  • 1Department of Medicine B, Hjørring-Brønderslev Hospital, Denmark.

Scandinavian Journal of Clinical and Laboratory Investigation
|November 14, 1997
PubMed
Summary
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Omega-3 polyunsaturated fatty acids (PUFA) did not lower endothelin-1 (ET-1) levels in healthy adults. High doses of n-3 PUFA may even increase ET-1, a potent vasoconstrictor.

Area of Science:

  • Cardiovascular Science
  • Nutritional Biochemistry

Background:

  • Endothelin-1 (ET-1) is the most potent vasoconstrictor known.
  • The potential effects of n-3 polyunsaturated fatty acids (PUFA) on ET-1 levels require investigation.

Purpose of the Study:

  • To investigate the effect of different doses of n-3 PUFA on plasma ET-1 levels in humans.

Main Methods:

  • Study 1: 40 healthy volunteers received a single 20g dose of n-3 or n-6 PUFA. Plasma ET-1 measured after 14 hours.
  • Study 2: 32 subjects received 0.65g of n-3 PUFA or a fat mixture daily for 12 weeks.
  • Study 3: 22 individuals received 4g of n-3 PUFA daily for 6 weeks.

Main Results:

  • No significant changes in plasma ET-1 were observed after a single 20g dose of n-3 PUFA compared to baseline.

Related Experiment Videos

  • No changes in plasma ET-1 were found after 12 weeks of 0.65g daily n-3 PUFA supplementation.
  • A significant increase in plasma ET-1 was observed in the group receiving 4g of n-3 PUFA daily for 6 weeks.

    • Conclusions:

    • N-3 PUFAs do not appear to lower plasma ET-1 levels.
    • High-dose n-3 PUFA supplementation may increase plasma ET-1 levels.