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Moderate beer consumption and positive biochemical changes in patients with coronary atherosclerosis
S Gorinstein1, M Zemser, M Berliner
1School of Pharmacy, Hebrew University of Jerusalem, Israel. gorin@cc.huji.ac.il
Insights
Moderate beer consumption in patients with coronary artery disease (CAD) showed favorable biochemical changes. A short period of daily beer intake improved HDL-C levels and increased tocopherol antioxidants, suggesting potential CAD prevention benefits.
Area of Science:
- Cardiovascular Medicine
- Nutritional Biochemistry
- Clinical Nutrition
Background:
- Coronary artery disease (CAD) poses a significant global health challenge.
- Lipid metabolism and antioxidant status are critical factors in CAD progression.
- The impact of moderate alcohol consumption, specifically beer, on these markers in CAD patients requires further investigation.
Purpose of the Study:
- To assess the effects of moderate beer consumption on lipid profiles and antioxidant activity in male patients diagnosed with CAD.
- To determine if a short-term, controlled beer intake can influence key biochemical indicators relevant to cardiovascular health.
Main Methods:
- A randomized controlled trial involving 48 male patients with CAD who were non-consumers of alcohol.
- Participants were divided into an experimental group (EG) consuming 330 ml of beer daily for 30 days and a control group (CG) abstaining from alcohol.
- Biochemical analyses included total cholesterol, LDL-C, HDL-C, total tocopherol, and alpha-tocopherol.
Main Results:
- The experimental group (EG) exhibited a trend towards increased HDL-C levels.
- A statistically significant increase in total tocopherol (P < 0.025) and alpha-tocopherol (P < 0.025) was observed exclusively in the EG.
- No significant changes were noted in the control group.
Conclusions:
- Even brief, moderate beer consumption can induce beneficial biochemical alterations in the blood of CAD patients.
- These changes, particularly the rise in HDL-C and tocopherol levels, are recognized indicators for CAD prevention.
- Moderate beer intake may represent a potential adjunct strategy in managing cardiovascular risk factors.
Objectives:
The aim of this study was to evaluate the influence of moderate beer consumption on lipid metabolism and antioxidant activity in patients (pts) with coronary artery disease (CAD).
Subjects:
Forty-eight male pts with CAD not alcohol beverages consumers were randomly divided into experimental (EG) and control (CG) groups, 24 pts each.
Setting:
Rehovot University Hospital, Israel.
Intervention:
Every patient of the EG during a period of 30 consecutive days consumed 330 ml of Maccabee beer (> 20 g of alcohol). The pts of the CG did not consume alcohol during the trial period.
Methods:
A wide range of tests including total cholesterol, LDL-C, HDL-C, total tocopherol and alpha-tocopherol.
Results:
Only in the pts of the EG were found a tendency to an increase of the level of HDL-C and a statistically significant rise in the level of total tocopherol (P < 0.025) and alpha-tocopherol (P < 0.025).
Conclusions:
Even a short period of moderate beer consumption leads to some favourable biochemical changes in blood of pts with CAD which are widely regarded as indicators of CAD prevention.