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Induction of HIV-1 specific mucosal immune responses by DNA vaccination
Y Asakura1, J Hinkula, A C Leandersson
1Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden.
Scandinavian Journal of Immunology
|November 14, 1997
Abstract:
DNA vaccination has been shown to induce immunity against several different pathogens including HIV-1. The authors demonstrate here that administration of DNA vaccines via the intranasal route is sufficient to induce immune responses both at distal mucosal sites and systemically. Since transmission of HIV-1 occurs largely across mucosal surfaces, the intranasal route provides a further means of application for DNA immunization.