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Related Experiment Videos

Strychnine convulsions in cockerels

T Ookawa

    Poultry Science
    |May 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Strychnine nitrate induced typical convulsions in chickens of all ages. However, the same dose did not produce strychnine spikes in the Wulst electroencephalogram (EEG) in either young or adult birds.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Veterinary Medicine

    Background:

    • Strychnine is a potent neurotoxin known to cause convulsions.
    • Understanding strychnine's effects across different avian developmental stages is crucial for toxicological studies.

    Purpose of the Study:

    • To investigate the convulsive effects of strychnine nitrate in cockerels and adult hens.
    • To examine electroencephalogram (EEG) changes, specifically strychnine spikes, in the Wulst region following strychnine administration.

    Main Methods:

    • Intravenous administration of strychnine nitrate (0.85 mg/kg) to cockerels (4-12 weeks) and adult hens.
    • Observation of behavioral convulsive patterns.
    • Recording of Wulst EEG to detect strychnine spikes.

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    Main Results:

    • All birds, regardless of age, exhibited typical strychnine-induced convulsions, including excitement, opisthotonos, and tonic-clonic seizures.
    • The intravenous dose of 0.85 mg/kg strychnine nitrate did not induce strychnine spikes in the Wulst EEG in either cockerels or adult hens.

    Conclusions:

    • Strychnine reliably induces convulsions in chickens across developmental stages.
    • Wulst EEG monitoring may not be a sensitive indicator for strychnine's neurotoxic effects at this dosage in avian models.