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Rewards in practice from chrono-meta-analyses 'recycling' heart rate, ectopy, ischemia and blood pressure information

F Halberg1, G Cornélissen, K Otsuka

  • 1Chronobiology Laboratories, University of Minnesota, Minneapolis, USA.

Journal of Medical Engineering & Technology
|November 14, 1997
PubMed

Insights

This study reveals that both atenolol and diltiazem reduce ischemia duration in coronary artery disease patients. Analyzing circadian and circaseptan rhythms helps optimize drug timing and monitor treatment effectiveness.

Area of Science:

  • Cardiology
  • Chronobiology
  • Pharmacology

Background:

  • Coronary artery disease (CAD) management involves monitoring heart rate and ischemia duration.
  • Circadian (about-daily) and circaseptan (about-weekly) rhythms influence cardiovascular variables.
  • Understanding treatment effects on these rhythms is crucial for optimizing patient care.

Purpose of the Study:

  • To re-analyze existing data on heart rate and ischemia duration in CAD patients.
  • To assess circadian and circaseptan changes in these variables under placebo, atenolol, and diltiazem treatment.
  • To evaluate the impact of atenolol and diltiazem on cardiovascular rhythm characteristics.

Main Methods:

  • Re-analysis of previously published average curves of heart rate and ischemia duration.
  • Assessment of circadian and circaseptan patterns in cardiovascular variables.
  • Comparison of rhythm characteristics between placebo and drug treatment (atenolol, diltiazem).

Main Results:

  • A circaseptan pattern was observed for ischemia duration and heart rate.
  • Both atenolol and diltiazem decreased ischemia duration.
  • Atenolol, but not diltiazem, affected circadian amplitude and acrophase of ischemia duration.
  • Both drugs lowered heart rate and its circadian amplitude and 24-h standard deviation, with atenolol showing a more pronounced effect.

Conclusions:

  • Circadian and circaseptan rhythms and their modulation by atenolol and diltiazem are important in CAD.
  • Timing of drug administration based on chronobiologic principles can optimize treatment.
  • Chronobiologic surveillance via implantable devices can validate therapy and provide early warnings of disease risk.

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