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Strains of glycopeptide-resistant Enterococcus faecium can alter their van genotypes during an outbreak
N Woodford1, P R Chadwick, D Morrison
1Laboratory of Hospital Infection, Central Public Health Laboratory, London, United Kingdom. nwoodfor@phls.co.uk
Journal of Clinical Microbiology
|November 14, 1997
Abstract:
Two isolates of Enterococcus faecium with VanA glycopeptide resistance were isolated during a hospital outbreak of E. faecium with plasmid-mediated VanB resistance. Both were found to be identical to the VanB outbreak strain by pulsed-field gel electrophoresis. The genotype of this strain changed from vanB to vanA through an intermediate isolate that contained both the vanA and vanB gene clusters on distinct plasmids.