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Related Experiment Videos

Basic fibroblast growth factor-induced seizures in rats

Z Liu1, G L Holmes

  • 1Department of Neurology, Harvard Medical School, Children's Hospital, Boston, MA 02115, USA. liu-z@al.tch.harvard.edu

Neuroscience Letters
|November 14, 1997
PubMed
Summary

Basic fibroblast growth factor (FGF2) can acutely trigger seizures and alter hippocampal electrical activity in rats. This finding reveals a novel, rapid effect of FGF2 beyond its known neurotrophic roles.

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Area of Science:

  • Neuroscience
  • Neurophysiology

Background:

  • Basic fibroblast growth factor (FGF2) is known for its neurotrophic effects on hippocampal neurons.
  • The acute impact of FGF2 on hippocampal electrical activity in vivo remains uninvestigated.

Purpose of the Study:

  • To investigate the acute effects of FGF2 on hippocampal electroencephalographic (EEG) activity and behavior in freely moving animals.

Main Methods:

  • Two doses of FGF2 (50 ng and 25 ng) were injected into the ventral hippocampus of rats.
  • EEG recordings and behavioral observations were used to monitor seizure activity.

Main Results:

  • A 50 ng dose of FGF2 induced immediate EEG ictal discharges and behavioral seizures lasting approximately 2 hours in 7/9 rats.
  • A 25 ng dose of FGF2 induced seizures of about 60 minutes in 3/7 rats.

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  • Heat-inactivated FGF2 did not produce any significant EEG or behavioral changes.

    • Conclusions:

    • Basic fibroblast growth factor (FGF2) has acute pro-convulsant effects on the hippocampus.
    • FGF2 can rapidly alter hippocampal neuronal electrical activity, leading to seizures in vivo.