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Haemodialysis with charcoal haemoperfusion
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
|January 1, 1976
Summary
This study explored combining activated charcoal hemoperfusion with hemodialysis. The combined treatment enhanced clearance of creatinine and urate, but caused a platelet reduction, warranting further investigation.
Area of Science:
- Nephrology
- Biomedical Engineering
Background:
- Hemodialysis is a vital treatment for kidney failure.
- Activated charcoal hemoperfusion can remove certain toxins from blood.
- Combining these therapies may offer enhanced waste removal.
Purpose of the Study:
- To evaluate the efficacy and safety of combined hemodialysis and activated charcoal hemoperfusion.
- To assess the impact on plasma clearance of various substances.
- To investigate effects on blood pressure and platelet counts.
Main Methods:
- Two patients underwent combined hemodialysis-hemoperfusion for 2 hours during a 5-hour dialysis session.
- An activated charcoal hemoperfusion device (300g charcoal) was used.
- Blood pressure and plasma clearances were monitored.
Main Results:
- Combined treatment increased plasma clearance of creatinine and urate.
- Creatinine and urate removal during 2 hours of combined therapy was substantial compared to 5-hour hemodialysis alone.
- No significant additional urea or phosphate removal was observed.
- A 20-30% terminal platelet reduction occurred with combined treatment.
Conclusions:
- Combined hemodialysis and activated charcoal hemoperfusion shows potential for improved waste product clearance.
- The therapy may be associated with a decrease in platelet count.
- Further research is recommended to explore this combined treatment modality.