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Effect of locust poison on neuromembrane functional activity
A Saghyan1, A Hunanian, S Ayrapetyan
1Biophysics Center, Armenian NAS, Yerevan, Armenia.
General Pharmacology
|November 14, 1997
Abstract:
1. The effect of locust poison (LP) on membrane excitability, chemosensitivity and Na-K pump activity was studied. 2. LP in a concentration of 10(-4) mg/ml has a potential independent blocking effect on neuromembrane excitability. 3. LP has an activation effect on Na-K pump-induced membrane hyperpolarization. 4. In a concentration higher than 10(-4) mg/ml, LP leads to a decrease in the acetylcholine-induced current and to an increase in this current after the washout of LP from the medium.