Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The muscle motor: 'simultaneous' levers or sequential impulses?

G F Elliott1, C R Worthington

  • 1Open University Oxford Research Unit, UK. g.f.elliott@open.ac.uk

International Journal of Biological Macromolecules
|November 14, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

X-RAY STUDIES ON NERVE AND PHOTORECEPTORS.

Annals of the New York Academy of Sciences·2017
Same author

Along the road not taken: how many myosin heads act on a single actin filament at any instant in working muscle?

Progress in biophysics and molecular biology·2011
Same author

Calcium-dependence of Donnan potentials in glycerinated rabbit psoas muscle in rigor, at and beyond filament overlap; a role for titin in the contractile process.

Cell calcium·2011
Same author

Ancient Traces of Antiseptic Treatment in Medicine and Surgery.

British medical journal·2010
Same author

Remarkable Specimen of Disease in Bone.

British medical journal·2010
Same author

The Germ-Theory.

British medical journal·2010

A new sequential impulsive model for actin-myosin interactions explains muscle physiology phenomena. This model uses step-size distance and sequential forces to elucidate puzzling data and predict high ATPase values in muscle.

Area of Science:

  • Muscle physiology
  • Biophysics
  • Molecular motors

Background:

  • Existing models of actin-myosin interaction face limitations in explaining certain muscle physiology phenomena.
  • Previous work established the step-size distance equation (z = u/n) relating step-size distance, actin filament velocity, and ATP splitting rate.

Purpose of the Study:

  • To introduce a sequential impulsive model for actin-myosin interactions.
  • To elucidate unexplained data in muscle physiology literature.
  • To predict high ATPase values observed in intact muscle.

Main Methods:

  • Utilized the previously developed step-size distance equation (z = u/n).
  • Introduced the concept of sequential impulsive contractile forces along actin-myosin trains.
  • Applied the model to explain existing experimental data and predict new findings.

Related Experiment Videos

Main Results:

  • The sequential impulsive model successfully explains previously puzzling data in muscle physiology.
  • The model predicts high ATPase values in intact muscle, aligning with recent experimental findings.
  • It offers a potentially superior explanation for muscle contraction mechanisms compared to simultaneous lever models.

Conclusions:

  • A sequential impulsive model provides a more comprehensive explanation for actin-myosin interactions in muscle.
  • This model advances our understanding of muscle physiology and the underlying molecular mechanisms.
  • It highlights the importance of sequential force application in muscle contraction.