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Related Experiment Videos

Acquired transplant tolerance

N Perico1, G Remuzzi

  • 1Department of Transplant Immunology and Innovative Antirejection Therapies, Ospedali Riuniti, Mario Negri Institute for Pharmacological Research, Bergamo, Italy.

International Journal of Clinical & Laboratory Research
|January 1, 1997
PubMed
Summary
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Achieving long-term organ transplant survival without immunosuppressants is possible through microchimerism or thymus-based tolerance. Novel strategies like oral alloantigen administration show promise for indefinite graft survival.

Area of Science:

  • Transplantation immunology
  • Graft acceptance and tolerance
  • Immunosuppressive therapy

Background:

  • Long-term survival of vascularized organs without immunosuppressants has been achieved in animal models.
  • Spontaneous drug-free graft survival in humans is occasionally reported after immunosuppressant withdrawal.
  • Donor 'passenger' leukocytes migrating from the graft to recipient tissues establish microchimerism, potentially inducing tolerance.

Purpose of the Study:

  • To explore mechanisms of graft acceptance and long-term survival without immunosuppression.
  • To investigate strategies for enhancing organ transplant tolerance.
  • To identify novel approaches for achieving indefinite graft survival.

Main Methods:

  • Analysis of leukocyte migration patterns in different organ grafts (liver, kidney, heart).

Related Experiment Videos

  • Evaluation of perioperative donor bone marrow infusion to increase donor leukocyte load.
  • Investigating the role of the thymus in inducing donor-specific tolerance via intrathymic donor cell injection.
  • Exploring oral administration of alloantigens in a rat cardiac transplant model.

    • Main Results:

    • Leukocyte migration is less pronounced in kidney and heart grafts compared to liver grafts.
    • Perioperative bone marrow infusion aims to enhance acceptance of less tolerogenic organs.
    • Intrathymic donor cell injection can induce donor-specific tolerance by eliminating alloreactive T-cells.
    • Oral alloantigen administration shows potential in a rat cardiac transplant model.

    Conclusions:

    • Microchimerism and thymus-mediated tolerance are key factors in long-term graft survival.
    • Novel strategies like bone marrow infusion and oral alloantigen administration offer new avenues for transplant tolerance.
    • Further research is needed to translate these findings into human clinical applications for indefinite graft survival.