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Autoimmune progesterone dermatitis: effective prophylactic treatment with danazol
E Shahar1, R Bergman, S Pollack
1Institute of Allergy, Clinical Immunology, and AIDS, Rambam Medical Center, Haifa, Israel.
Background:
Autoimmune progesterone dermatitis is a rare condition appearing during the perimenstrual period or following progesterone treatment. Various treatment modalities have been suggested, but most have proved to be ineffective.
Methods:
We used the anabolic androgen danazol as a preventive treatment for recurrent episodes of autoimmune progesterone dermatitis in two young women. The treatment regimen consisted of 200 mg danazol twice daily, starting 1-2 days before the expected date of each menses and continuing for 3 days thereafter.
Results:
This treatment regimen proved to be highly effective in preventing the eruptions in these two patients.
Conclusions:
Patients with autoimmune progesterone dermatitis may benefit from prophylactic treatment with danazol.