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Autoimmune progesterone dermatitis: effective prophylactic treatment with danazol
E Shahar1, R Bergman, S Pollack
1Institute of Allergy, Clinical Immunology, and AIDS, Rambam Medical Center, Haifa, Israel.
International Journal of Dermatology
|November 14, 1997
Summary
Autoimmune progesterone dermatitis can be effectively prevented using danazol. This anabolic androgen treatment offers a promising solution for recurrent episodes of this rare condition.
Area of Science:
- Dermatology
- Endocrinology
- Immunology
Background:
- Autoimmune progesterone dermatitis is a rare condition linked to the perimenstrual period or progesterone therapy.
- Existing treatments for this condition have shown limited efficacy.
Observation:
- Two young women with recurrent autoimmune progesterone dermatitis were treated preventively with danazol.
- The treatment involved 200 mg of danazol twice daily, initiated before and continued for three days after the expected menses.
Findings:
- The danazol regimen was highly effective in preventing eruptions in both patients.
- Prophylactic danazol demonstrated significant success in managing recurrent autoimmune progesterone dermatitis.
Implications:
- Danazol presents a viable prophylactic treatment option for autoimmune progesterone dermatitis.
- This study suggests danazol as a beneficial therapy for patients suffering from this rare dermatological condition.