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Related Experiment Videos

Age changes in signal transduction and gene expression

G S Roth1

  • 1Laboratory of Cellular and Molecular Biology, National Institutes of Health, National Institute on Aging, Baltimore, MD 21224, USA.

Mechanisms of Ageing and Development
|November 14, 1997
PubMed
Summary

Aging impairs physiological functions like motor control and DNA synthesis due to altered gene expression. Research investigates mechanisms behind these changes, including dopamine receptor loss and impaired cell signaling pathways.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Molecular Biology

Background:

  • Aging alters physiological and behavioral processes.
  • Hormones and neurotransmitters control these processes, changing with age.
  • Altered gene expression is critical in age-related functional decline.

Purpose of the Study:

  • Elucidate mechanisms of age-related changes in hormone and neurotransmitter-controlled processes.
  • Investigate the loss of striatal dopaminergic motor control.
  • Examine impaired stimulation of hepatocyte DNA synthesis.

Main Methods:

  • Studied loss of striatal D2 dopamine receptors and its causes (neuronal death, reduced gene expression).
  • Utilized adenoviral vectors to express functional D2 receptors in rodent brains.

Related Experiment Videos

  • Assessed DNA synthesis stimulation in aged versus young rat hepatocytes, analyzing signaling pathways.

    • Main Results:

    • D2 dopamine receptor loss contributes to reduced motor control in aging.
    • Hepatocyte DNA synthesis stimulation is reduced in aged rats, independent of receptor loss.
    • Impaired MAP Kinase pathway signaling and shifts to alternative pathways observed in aged cells.

    Conclusions:

    • Altered gene expression during aging significantly impacts signal transduction.
    • These molecular changes underlie functional impairments in physiological and behavioral processes.
    • Further research is needed on neuronal death and gene expression links.