Influence of some antirheumatic drugs and cytostatics on urinary enzyme level

In experiments with rats, the influence of the treatment with sodium salicylate (350 mg/kg), phenylbutazone (100 mg/kg), cyclophosphamide (5 mg/kg), 6-mercaptopurine (25 mg/kg) and D-penicillamine (50 mg/kg), on urinary lactate dehydrogenase, leucine aminopeptidase and alanine aminopeptidase was investigated. All these drugs caused an increase in the enzyme levels in urine. In the case of sodium salicylate, the increase occurred only after the first administration of the drug; phenylbutazone caused a gradual increase of the enzymes. Cytostatic drugs caused an increase in the level of the investigated enzymes in urine with a maximum after 1 week of treatment.