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Nephrogenic adenoma--a study with special reference to clinical presentation
R Peeker1, F Aldenborg, M Fall
1Department of Urology, Sahlgrenska University Hospital, Göteborg, Sweden.
British Journal of Urology
|November 14, 1997
Summary
Nephrogenic adenoma, a rare urinary tract lesion, often presents without symptoms and is diagnosed histologically. Transurethral resection effectively treats symptomatic cases and recurrence is possible.
Area of Science:
- Urology
- Pathology
- Oncology
Background:
- Nephrogenic adenoma is a rare, benign lesion of the urinary tract mucosa.
- It can mimic malignant tumors or chronic cystitis, often leading to delayed diagnosis.
Purpose of the Study:
- To investigate the clinical characteristics of nephrogenic adenoma, including symptoms, location, and endoscopic appearance.
- To evaluate treatment outcomes and recurrence rates for nephrogenic adenoma.
- To explore the potential link between urothelial trauma and nephrogenic adenoma development.
Main Methods:
- Retrospective review of 31 patients diagnosed with nephrogenic adenoma between 1980 and 1996.
- Analysis of patient records for symptomatology, endoscopic findings, histopathology, and treatment outcomes.
- Assessment of recurrence frequency following surgical intervention.
Main Results:
- Lesions were identified in the bladder, bulbar urethra, urethral diverticula, and prostatic urethra.
- Common symptoms included hematuria, urinary frequency, and bladder pain; however, 12 patients were asymptomatic.
- A history of urothelial trauma was noted in 27 patients. Recurrence occurred in 7 patients, and transurethral resection was effective for symptomatic relief.
Conclusions:
- Nephrogenic adenoma is rarely suspected clinically and is typically diagnosed via histology.
- The study suggests nephrogenic adenoma may arise as a metaplastic response to urothelial trauma.
- Transurethral resection is an effective treatment for symptomatic nephrogenic adenoma.