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Related Experiment Videos

Urinary free cortisol excretion in depression

B J Carroll, G C Curtis, B M Davies

    Psychological Medicine
    |February 1, 1976
    PubMed
    Summary
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    Depressed patients show elevated urinary free cortisol (UFC) levels, with over 40% in the range of Cushing's disease. Treatment normalized UFC excretion, indicating its utility in psychoendocrine research.

    Area of Science:

    • Endocrinology
    • Psychiatry
    • Neuroscience

    Background:

    • Elevated cortisol levels are implicated in depression.
    • Adrenal cortical activation is a key area in psychoendocrine research.

    Purpose of the Study:

    • To investigate urinary free cortisol (UFC) excretion in depressed patients compared to other psychiatric inpatients.
    • To assess the clinical utility of UFC determination in diagnosing and monitoring depression.

    Main Methods:

    • Measurement of daily urinary free cortisol (UFC) excretion in 60 depressed inpatients and 35 psychiatric inpatients with other disorders.
    • Comparison of UFC levels between groups and correlation with depression subtypes and treatment outcomes.

    Main Results:

    Related Experiment Videos

  • Depressed patients exhibited significantly higher daily UFC values than other psychiatric patients.
  • Over 40% of depressed patients had UFC levels comparable to those seen in Cushing's disease.
  • Following treatment, UFC excretion normalized in the depressed patient group.
  • Depressive neuroses showed lower UFC excretion than unipolar or bipolar depression.

    • Conclusions:

    • Urinary free cortisol (UFC) determination is a valuable indicator of adrenal cortical activation in depression.
    • UFC measurement can aid in the diagnosis and understanding of depression's neuroendocrine aspects.
    • The study recommends UFC determination for psychoendocrine research.