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Adenoviral vectors for gene transfer
I Kovesdi1, D E Brough, J T Bruder
1GenVec Inc., Rockville, MD 20852, USA. kovesdi@genvec.com
Current Opinion in Biotechnology
|November 14, 1997
Summary
Adenoviruses are effective gene expression vectors. Recent in vivo applications highlight challenges in gene transfer, driving new vector development to address structural, immunological, and targeting issues for gene therapy.
Area of Science:
- Molecular Biology
- Gene Therapy
- Virology
Background:
- Adenoviruses emerged as potent gene expression vectors in the early 1980s.
- Their utility has expanded, with a recent surge in interest for in vivo applications.
Purpose of the Study:
- To address challenges in heterologous gene transfer using adenoviral vectors in vivo.
- To spur renewed efforts in adenoviral vector development for gene therapy.
Main Methods:
- Focus on overcoming structural limitations of adenoviral vectors.
- Addressing immunological barriers to in vivo gene transfer.
- Developing strategies for targeted gene delivery using adenoviral systems.
Main Results:
- Identification of key structural hurdles in adenoviral vector design.
- Understanding immunological responses that impede in vivo gene therapy.
- Progress in engineering adenoviral vectors for enhanced targeting capabilities.
Conclusions:
- Adenoviral vectors remain promising for gene therapy.
- Ongoing research is crucial to resolve in vivo application challenges.
- Advancements in vector development are essential for successful gene therapy outcomes.