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Replication of murine coronaviruses in mouse embryonic stem cell lines in vitro
1Department of Animal Pathology, University of Tokyo, Japan.
Experimental Animals
|November 14, 1997
Abstract:
Replication of murine coronaviruses in eight mouse embryonic stem (ES) cell lines of several genetic backgrounds was examined. Both mouse hepatitis virus (MHV) type 2 and MHV, strain A59 replicated well with no or minimal cytopathic effect in all the ES cell lines tested. The results suggest the possibility that MHV-infected ES cells may disseminate MHV in mouse colonies due to embryo manipulation.