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Tilidine does not affect human sphincter of Oddi motility--a randomized, controlled study
T Wehrmann1, D Rausch, K U Seiler
1Department of Internal Medicine II, J. W. Goethe-University Hospital, Frankfurt am Main, Germany.
Alimentary Pharmacology & Therapeutics
|November 14, 1997
Summary
Tilidine does not affect sphincter of Oddi motility, unlike pentazocine. This suggests tilidine is suitable for endoscopic manometry and pain relief in pancreatobiliary conditions.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Sphincter of Oddi (SO) dysfunction can cause significant pancreatobiliary pain.
- Accurate assessment of SO motility is crucial for diagnosis and management.
- Opioid analgesics can influence SO motility, potentially complicating manometry.
Purpose of the Study:
- To compare the effects of intravenous pentazocine and tilidine on sphincter of Oddi motility.
- To determine the safety of using these agents during endoscopic manometry.
Main Methods:
- A prospective, double-blind study involving 20 patients with suspected SO dysfunction.
- Endoscopic manometry was used to measure SO motility.
- Motility was assessed after saline injection and randomized administration of pentazocine (30 mg IV) or tilidine (50 mg IV).
Main Results:
- Pentazocine significantly increased SO baseline pressure and contraction amplitude.
- Tilidine did not significantly alter SO baseline pressure or contraction amplitude.
- Neither drug affected the frequency or duration of SO contractions.
Conclusions:
- Tilidine (50 mg IV) does not impact sphincter of Oddi motility.
- Pentazocine (30 mg IV) increases SO baseline pressure and contraction amplitude.
- Tilidine is a viable option for analgesia and during manometry in patients with pancreatobiliary disease.