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Sample collection, processing and storage

M T Landi¹, N Caporaso

¹Genetic Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7360, USA.

IARC Scientific Publications

|January 1, 1997

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Collecting biospecimens for biomarker studies in epidemiology requires careful attention to processing, storage, and quality control. Proper handling ensures the validity of results derived from these valuable biological samples.

Area of Science:

Epidemiology
Molecular Biology
Biomarker Research

Background:

Advancements in molecular biology enable biomarker use in epidemiology.
Biospecimen banking for cohort studies presents unique challenges.
Clinical sample handling provides a basis but requires epidemiological adaptation.

Purpose of the Study:

To review critical issues in biospecimen inclusion for epidemiological studies.
To highlight methodological considerations for valid biomarker utilization.
To emphasize the importance of quality control in biospecimen handling.

Main Methods:

Review of current practices and challenges in biospecimen collection and processing.
Examination of various biospecimen types used in epidemiological research.

Related Experiment Videos

Discussion of factors impacting sample integrity and biomarker stability.

Main Results:

Technical advances increase feasibility but also complexity and cost.
Diverse biospecimen types (blood, urine, tissue, air, etc.) are utilized.
Potential distortions from processing, storage, shipping, and timing are identified.

Conclusions:

Meticulous attention to biospecimen processing and handling is crucial for validity.
Quality control protocols are essential for reliable epidemiological biomarker studies.
Careful management of biospecimens maximizes the potential of biomarker discovery.