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Drug therapy for ulcerative colitis during pregnancy
1Hôpital Saint-Louis, Paris, France.
European Journal of Gastroenterology & Hepatology
|November 14, 1997
Summary
Women with ulcerative colitis (UC) can safely conceive during remission. Standard treatments like steroids and salicylates are generally safe during pregnancy, with azathioprine and cyclosporine considered under specific conditions for ulcerative colitis management.
Area of Science:
- Gastroenterology and Hepatology
- Obstetrics and Gynecology
- Internal Medicine
Background:
- Ulcerative colitis (UC) frequently affects women of reproductive age.
- Pregnancy in women with UC requires careful management strategies.
Purpose of the Study:
- To provide guidance on managing ulcerative colitis during pregnancy.
- To inform optimal conception timing and medication use for pregnant women with UC.
Main Methods:
- Review of current literature and clinical guidelines for UC management in pregnancy.
- Analysis of safety profiles for common UC medications during gestation.
Main Results:
- Conception is recommended during quiescent disease periods.
- Steroids and salicylates (e.g., mesalazine up to 2g/day) are generally safe.
- Azathioprine can be continued for clear indications.
- Cyclosporine is a viable option for acute, steroid-refractory UC, as a pre-surgical alternative.
Conclusions:
- Pregnant women with UC can achieve successful outcomes with appropriate management.
- Medication choices should be individualized based on disease activity and safety profiles.
- Maintaining quiescent UC is key for favorable pregnancy and maternal outcomes.