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Sciatic nerve: paradoxic hypertrophy after amputation in young patients

S C Hill1, A R Baker, N W Barton

  • 1Department of Diagnostic Radiology, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892-1182, USA.

Radiology
|November 14, 1997
PubMed
Summary

Young patients who underwent above-knee amputation showed sciatic nerve hypertrophy. This differs from nerve atrophy seen in older individuals, highlighting age-related differences in nerve response to amputation.

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Area of Science:

  • Orthopedic Surgery
  • Neurology
  • Radiology

Background:

  • Sciatic nerve changes post-amputation are not fully understood.
  • Previous studies suggested nerve atrophy in older patients.

Purpose of the Study:

  • To evaluate sciatic nerve appearance after leg amputation in young patients.
  • To compare findings with previous reports on nerve changes post-amputation.

Main Methods:

  • Magnetic resonance (MR) imaging was used in seven patients (age 11-19 years) post-above-knee amputation.
  • Sciatic nerve enlargement was assessed and correlated with time since amputation.
  • Preoperative MR images and a leg-sparing procedure served as controls.

Main Results:

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  • All seven patients exhibited marked sciatic nerve enlargement in the amputated leg stump.
  • Nerve enlargement extended 8-27 cm from the transection point.
  • No enlargement was observed in the contralateral leg or in preoperative scans.

    • Conclusions:

    • Hypertrophy of the sciatic nerve is observed after above-knee amputation in young patients.
    • This finding contrasts with reported nerve atrophy in older patients.
    • Age appears to influence sciatic nerve response to amputation.