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Related Experiment Videos

Thromboembolic disease

V Lopez-Majano

    Respiration; International Review of Thoracic Diseases
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Deep vein thrombosis in the legs is common in patients with pulmonary embolism. Studying leg venous circulation is crucial for identifying the primary cause of pulmonary embolism.

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    Area of Science:

    • Nuclear Medicine
    • Vascular Medicine
    • Radiology

    Background:

    • Pulmonary embolism (PE) is a significant cause of morbidity and mortality.
    • The origin of thrombi causing PE is often attributed to the deep venous system of the lower extremities.
    • Identifying the source of emboli is critical for effective treatment and prevention.

    Purpose of the Study:

    • To investigate the incidence of deep vein thrombophlebitis in patients diagnosed with pulmonary embolism.
    • To assess the correlation between lower extremity venous circulation abnormalities and pulmonary arterial blood flow.
    • To determine the role of the deep venous system of the extremities as the primary source of pulmonary emboli.

    Main Methods:

    • Utilized technetium-99m labeled albumin macroaggregates for imaging.

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  • Performed perfusion lung scintigraphy and phlebography in 52 patients with pulmonary embolism.
  • Employed a gamma camera with a data processor for image acquisition and analysis.

    • Main Results:

    • All 52 patients exhibited abnormal perfusion lung scintigrams.
    • 42 patients (81%) also presented with abnormal phlebograms, indicating deep vein thrombophlebitis.
    • In half of the patients, lung perfusion normalized by the time phlebograms were obtained, suggesting resolution or altered flow dynamics.

    Conclusions:

    • Deep vein thrombophlebitis is highly prevalent in patients with pulmonary embolism.
    • The lower extremities serve as a major 'thrombi factory' contributing to PE.
    • Diagnostic evaluation of the deep venous circulation of the extremities is essential for elucidating the etiology of pulmonary embolism.