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Related Experiment Videos

Caspases and caspase inhibitors

P Villa1, S H Kaufmann, W C Earnshaw

  • 1Institute of Cell and Molecular Biology, University of Edinburgh, UK.

Trends in Biochemical Sciences
|November 14, 1997
PubMed
Summary

Caspases, or cysteine and aspartases, are key cell-death genes. This review covers caspase functions, human gene diversity, substrates, and inhibitors, advancing our understanding of apoptosis.

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Apoptotic execution mechanisms were poorly understood five years ago.
  • Cysteine and aspartases (caspases) have emerged as a critical class of cell-death genes.
  • Intensive research has focused on understanding caspase roles in programmed cell death.

Purpose of the Study:

  • To review the current knowledge on caspases.
  • To discuss the different classes of caspases.
  • To explore the significance of multiple caspase genes in humans.

Main Methods:

  • Literature review of recent studies on caspases.
  • Analysis of the known caspase substrate repertoire.
  • Examination of viral and pharmacological caspase inhibitors.

Main Results:

  • Identification of two main classes of caspases.
  • Hypotheses regarding the evolutionary reasons for human caspase gene multiplicity.
  • Compilation of a growing list of identified caspase substrates.
  • Overview of identified viral and pharmacological caspase inhibitors.

Conclusions:

  • Caspases are central mediators of apoptosis.
  • Further research is needed to fully elucidate caspase functions and regulation.
  • Understanding caspase inhibitors holds therapeutic potential for diseases involving apoptosis.

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