Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Long-term evaluation of bone-titanium interface in rat tibiae using light microscopy, transmission electron

F Takeshita1, Y Ayukawa, S Iyama

  • 1Prosthetic Dentistry II, Faculty of Dentistry, Kyushu University, Fukuoka, Japan.

Journal of Biomedical Materials Research
|November 14, 1997
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Precancerous niche remodelling dictates nascent tumour persistence.

Nature·2026
Same author

Usefulness of balanced steady-state free precession for portosystemic shunts prior to balloon-occluded retrograde transvenous obliteration.

Clinical radiology·2025
Same author

Platinum plus etoposide with durvalumab for extensive-stage small-cell lung cancer with untreated brain metastases: a multicenter, single-arm phase II trial (LOGiK2001, SPEED).

ESMO open·2025
Same author

Randomized, double-blind, crossover, placebo-controlled clinical trial to evaluate the effects of chicken hot water extract on insulin secretion.

European review for medical and pharmacological sciences·2022
Same author

Assessment of the efficacy of membrane filtration processes to remove human enteric viruses and the suitability of bacteriophages and a plant virus as surrogates for those viruses.

Water research·2017
Same author

Elimination of representative contaminant candidate list viruses, coxsackievirus, echovirus, hepatitis A virus, and norovirus, from water by coagulation processes.

Journal of hazardous materials·2016

Histologic and histometric analysis of the bone-titanium implant interface in rats shows increased bone contact over 2 years. Interfacial cells and unmineralized bone persist, influencing implant integration.

Area of Science:

  • Biomaterials Science
  • Orthopedic Research
  • Tissue Engineering

Background:

  • Osseointegration is crucial for dental and orthopedic implants.
  • Understanding the bone-titanium interface is key to improving implant success.
  • Long-term studies are needed to evaluate the stability of the bone-implant interface.

Purpose of the Study:

  • To histologically and histometrically evaluate the tibial bone-titanium (Ti) implant interface over 2 years in rats.
  • To assess the cellular and matrix components at the bone-Ti interface over time.
  • To quantify bone-implant contact and surrounding bone dimensions.

Main Methods:

  • Histologic and histometric analysis of tibial bone-titanium implants in male rats at 28 and 730 days.
  • Microscopic and transmission electron microscopic (TEM) observations.

Related Experiment Videos

  • Image-processing system analysis for bone contact percentage, thickness, and area.

    • Main Results:

    • At 28 days, newly formed bone nearly surrounded the implant, with some interposed fibroblastlike cells and an amorphous zone between bone and Ti.
    • At 730 days, bone showed a lamellar structure with significantly increased bone contact (89.9%) compared to 28 days (43.6%).
    • An amorphous zone and unmineralized bone persisted at the interface even after 2 years, with occasional cell remnants observed.

    Conclusions:

    • Bone-titanium implant integration improves significantly over 2 years, characterized by increased bone contact and maturity.
    • Interfacial cells and unmineralized bone layers remain present at the bone-Ti interface long-term.
    • These persistent interfacial components may play a role in the dynamic bone-implant interactions.