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Related Experiment Videos

T2 accuracy on a whole-body imager

W D Foltz1, J A Stainsby, G A Wright

  • 1Department of Medical Biophysics, University of Toronto, Ontario, Canada.

Magnetic Resonance in Medicine
|November 14, 1997
PubMed
Summary

Accurate in vivo T2 measurement for MR oximetry is crucial. This study introduces a method using composite pulses and RF cycling to prevent signal loss and reduce T1 dependence, achieving T2 accuracy within 5%.

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Biomedical Engineering
  • Medical Physics

Background:

  • Accurate in vivo T2 measurement is essential for MR oximetry, requiring precision within 5%.
  • Existing methods often suffer from signal loss, leading to T2 underestimation.
  • Imperfect radiofrequency (RF) pulses can cause T2 overestimation due to T1-dependent signal decay.

Purpose of the Study:

  • To develop an MR oximetry method that achieves T2 accuracy within 5% in vivo.
  • To minimize signal loss and T1 dependence in T2 measurements.
  • To improve the reliability of T2 measurements under RF and static field inhomogeneities.

Main Methods:

  • Utilized simple 90x180y90x composite pulses and optimized RF cycling patterns.
  • Implemented strategies to prevent signal loss during data acquisition.
  • Accounted for T1 signal decay during the composite pulse sequence.

Main Results:

  • The proposed method effectively prevents signal loss, a common issue in T2 measurements.
  • T1 dependence was significantly reduced, mitigating T2 overestimation.
  • Achieved T2 accuracy within the critical 5% threshold for MR oximetry.

Conclusions:

  • The combination of composite pulses and RF cycling enhances T2 accuracy for MR oximetry.
  • A simple correction scheme effectively compensates for T1-related errors.
  • This approach offers a robust solution for reliable in vivo T2 quantification.

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