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Biomimetic cyclization of cnicin to malacitanolide, a cytotoxic eudesmanolide from Centaurea malacitana
A F Barrero1, J E Oltra, V Morales
1Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Granada, Spain. afbarre@goliat.ugr.es
Journal of Natural Products
|November 14, 1997
Abstract:
Malacitanolide (2), a new eudesmanolide isolated from the aerial parts of Centaurea malacitana, was characterized spectroscopically. The synthesis of 2 from cnicin (1), via the epoxide 3, confirmed the structure and stereochemistry of malacitanolide, as well as its biogenetic relationship with 1. Cytotoxic activity values for 2 are significantly higher than for 1.