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Biphasic effects of pu-chung-i-chi-tang on sedation and excitation
1Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan.
The American Journal of Chinese Medicine
|January 1, 1997
Abstract:
The biphasic effects of Pu-Chung-I-Chi-Tang (PCT) on sedation and excitation in acute treatment or after one-week consecutive treatment were studied. The results indicated that PCT produces sedation in acute treatment and excitation after one-week consecutive treatment. The sedative mechanism of PCT in acute treatment might be due to an increase in serotonergic activity and a decrease in dopaminergic activity. However, the excitatory mechanism of PCT after one-week consecutive treatment might involve the increase in dopaminergic activity and the decrease in serotonergic activity.