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Cardiac lithomyxoma

C Basso1, M Valente, D Casarotto

  • 1Department of Pathology and Cardiovascular Surgery, University of Padua Medical School, Italy.

The American Journal of Cardiology
|November 14, 1997
PubMed
Summary
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Cardiac myxomas can exhibit significant calcification, appearing as partial or massive stone-like deposits. Histologic examination reveals specific findings like Gamma-Gandy bodies and metaplasia in calcified myxomas.

Area of Science:

  • Cardiovascular Pathology
  • Medical Imaging

Background:

  • Cardiac myxomas are the most common primary heart tumors.
  • Calcification is an infrequent finding in cardiac myxomas.

Purpose of the Study:

  • To investigate the prevalence and characteristics of calcification in cardiac myxomas.
  • To correlate imaging findings with histological features of calcified myxomas.

Main Methods:

  • Retrospective review of 102 consecutive cardiac myxoma cases.
  • Analysis of gross inspection, X-ray examinations, and histological findings.
  • Correlation of mineralization patterns with patient demographics and histology.

Main Results:

  • 10% of cardiac myxomas (10/102) showed heavy calcification on gross and X-ray.

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  • Partial calcification (n=6, mean age 56.8) and massive stone-like calcification (n=4, mean age 70) were observed.
  • Histology in partial calcification cases revealed Gamma-Gandy bodies (n=5), cartilaginous/bone metaplasia (n=2), and non-specific calcium deposits (n=1).

    • Conclusions:

    • Calcification occurs in a notable proportion of cardiac myxomas.
    • Different patterns of calcification may be associated with distinct histological features.
    • These findings are often incidental discoveries during autopsy or clinical workups.