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Transnasal hypophysectomy

S L Sellars, M B Bennett

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |May 29, 1976
    PubMed
    Summary
    This summary is machine-generated.

    This study details a transnasal trans-sphenoidal surgery for pituitary gland tumors in 21 patients. The technique showed complications including hemorrhage and diabetes insipidus, with one postoperative death.

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    Area of Science:

    • Neurosurgery
    • Endocrinology
    • Oncology

    Background:

    • Transsphenoidal surgery is a common approach for pituitary gland pathologies.
    • Hormone-dependent malignant diseases often require intervention impacting the pituitary gland.

    Purpose of the Study:

    • To describe the transnasal trans-sphenoidal surgical approach to the pituitary gland.
    • To report operative and post-operative experiences in patients with hormone-dependent malignant disease.

    Main Methods:

    • A transnasal trans-sphenoidal surgical technique was employed.
    • The study involved 21 patients diagnosed with hormone-dependent malignant disease.

    Main Results:

    • The procedure was abandoned in 2 patients due to intrasellar hemorrhage.

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  • One patient was found to have an empty sella.
  • Fifteen patients developed diabetes insipidus postoperatively.
  • One patient experienced a postoperative death.

    • Conclusions:

    • The transnasal trans-sphenoidal approach presents significant risks in patients with hormone-dependent malignant disease.
    • Complications such as hemorrhage and diabetes insipidus are notable.
    • Careful patient selection and surgical expertise are crucial for managing these complex cases.