Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

APUD cells, apudomas and the neural crest

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde

|May 29, 1976

Summary

The amine precursor uptake and decarboxylation (APUD) cell series primarily takes up amine precursors. While some APUD cells originate from neural crest and secrete hormones, a biochemical link may unite diverse APUD cell origins.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Entropy-based information gain approaches to detect and to characterize gene-gene and gene-environment interactions/correlations of complex diseases.

Genetic epidemiology·2011

Same author

Improvement of silicon solar cell performance through the use of thin film coatings.

Applied optics·2010

Same author

The diverse roles of J-proteins, the obligate Hsp70 co-chaperone.

Reviews of physiology, biochemistry and pharmacology·2006

Same author

A population-based study of immunohistochemical detection of p53 alteration in bladder cancer.

British journal of cancer·2004

Same author

Nickel-induced plasminogen activator inhibitor-1 expression inhibits the fibrinolytic activity of human airway epithelial cells.

Toxicology and applied pharmacology·2000

Same author

Gut endocrine cells in birds: an overview, with particular reference to the chemistry of gut peptides and the distribution, ontogeny, embryonic origin and differentiation of the endocrine cells.

Progress in histochemistry and cytochemistry·1999

Area of Science:

Endocrinology
Cell Biology
Developmental Biology

Background:

The amine precursor uptake and decarboxylation (APUD) cell series is characterized by amine precursor uptake and decarboxylation.
Historically, secretion of polypeptide hormones and neural crest origin were considered defining features.
Recent findings indicate a growing number of APUD cells elaborate polypeptide hormones.

Purpose of the Study:

To re-evaluate the defining characteristics of the APUD cell series.
To explore the common factors in the genesis of APUD cells and potentially other tumors.
To investigate the role of biochemical versus embryological relationships in APUD cell progenitor types.

Main Methods:

Literature review and synthesis of existing research on APUD cell characteristics.
Comparative analysis of embryological origins and biochemical functions of various APUD cell types.
Examination of evidence supporting or refuting neural crest derivation for all APUD cells.

Main Results:

The ability to take up and decarboxylate amine precursors remains a consistent feature of APUD cells.
Evidence suggests that not all APUD cells are derived from the neural crest, challenging a universal embryological origin.
A significant number of APUD cells are confirmed to elaborate polypeptide hormones.

Conclusions:

The commonality in APUD cell genesis may lie in biochemical relationships rather than a singular embryological origin.
The neural crest hypothesis for all APUD cell origins is not universally supported by current evidence.
Biochemical similarities among progenitor cells could be a unifying factor for the APUD cell series and other tumors.

Related Experiment Videos