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Pulmonary microcirculation during pulsatile and non pulsatile perfusion

H Konishi1, Y Sohara, S Endo

  • 1Department of Thoracic and Cardiovascular Surgery, Jichi Medical School, Tochigi, Japan.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|November 14, 1997
PubMed
Summary
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Non-pulsatile blood flow from rotary assist devices may impair organ microcirculation. This study observed heterogeneous capillary perfusion during non-pulsatile flow, suggesting potential functional deterioration.

Area of Science:

  • Cardiovascular Physiology
  • Biomedical Engineering

Background:

  • Rotary blood pumps are used as assist devices, but the impact of non-pulsatile perfusion on end organs requires verification.
  • Limited studies evaluate different perfusion mechanisms within tissue microcirculation.

Purpose of the Study:

  • To analyze pulmonary microcirculation using vital microscopic observation.
  • To compare capillary perfusion during pulsatile and non-pulsatile flow in rats.

Main Methods:

  • Wistar rats underwent right heart bypass using a roller pump, establishing non-pulsatile flow.
  • Pulmonary microcirculation was observed via vital microscopy during intravenous infusion of fluorescently tagged albumin.
  • Images were recorded using an ultra-sensitive SIT TV camera.

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Main Results:

  • Pulsatile flow from the native heart resulted in even pulmonary capillary network perfusion.
  • Non-pulsatile flow from the roller pump led to heterogeneous perfusion, displacing flow to arteriovenous shunts.
  • Capillary perfusion distribution was significantly different between pulsatile and non-pulsatile flow conditions.

Conclusions:

  • Non-pulsatile perfusion may negatively impact organ function due to heterogeneous microcirculatory distribution.
  • Further research is essential to understand the relationship between microcirculation and organ function under non-pulsatile flow conditions.