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Parallel dialysis normalizes serum chemistries during venovenous perfusion induced hyperthermia
R A Vertrees1, D J Deyo, W Tao
1Department of Surgery, University of Texas Medical Branch, Galveston 77555-0528, USA.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|November 14, 1997
Summary
Whole-body hyperthermia shows promise for treating cancer, but causes chemical imbalances. A novel veno-venous perfusion with dialysis system effectively controlled these derangements, maintaining normal chemistries during treatment.
Area of Science:
- Oncology
- Medical Technology
- Physiology
Background:
- Whole-body hyperthermia is being explored for systemic malignancy treatment.
- Current methods often lead to significant serum and urine chemistry derangements.
- Controlling these chemical imbalances is crucial for patient safety and treatment efficacy.
Purpose of the Study:
- To evaluate if a veno-venous perfusion induced hyperthermia (vv-PISH) system with an integrated dialysis component can prevent heat-induced chemistry changes.
- To assess the impact of vv-PISH with dialysis on key serum and urine chemistry parameters in a swine model.
Main Methods:
- Adult female Yorkshire swine were divided into two groups: perfusion only (P) and perfusion with dialysis (PD).
- Hyperthermia was induced using a computer-assisted veno-venous heat exchange system targeting a core temperature of 43°C for 120 minutes.
- The PD group utilized a parallel dialysis system to manage blood chemistries throughout the procedure.
Main Results:
- In the perfusion with dialysis (PD) group, all measured serum and urine chemistry variables remained within normal ranges.
- In contrast, the perfusion only (P) group exhibited significant deviations from normal ranges for creatinine, calcium, magnesium, alkaline phosphatase (ALKP), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH).
Conclusions:
- Veno-venous perfusion induced hyperthermia (vv-PISH) combined with a parallel dialysis system effectively normalizes serum and urine chemistry derangements.
- This integrated approach may reduce the incidence of electrolyte-associated complications during whole-body hyperthermia treatment.
- The findings support the potential of vv-PISH with dialysis as a safer method for heat-based cancer therapies.