Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Invasive Aspergillus sinusitis during bone marrow transplantation

C F Verschraegen1, K W van Besien, C Dignani

  • 1Section of Gynecology Medical Oncology, University of Texas, M. D. Anderson Cancer Center, Houston, USA.

Scandinavian Journal of Infectious Diseases
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intravenous Busulfan, Dimethylacetamide and neurotoxicity after high-dose pretransplant conditioning chemotherapy.

Bone marrow transplantation·2023
Same author

Romidepsin antagonism with CHOEP.

Leukemia·2023
Same author

Successful HLA haploidentical HSCT with post-transplant cyclophosphamide in Wiskott-Aldrich syndrome.

Bone marrow transplantation·2017
Same author

Fludarabine with pharmacokinetically guided IV busulfan is superior to fixed-dose delivery in pretransplant conditioning of AML/MDS patients.

Bone marrow transplantation·2016
Same author

Long-Term Results of CAP Therapy in Chronic Lymphocytic Leukemia.

Leukemia & lymphoma·2016
Same author

Pretransplant conditioning with fludarabine and IV busulfan, reduced toxicity and increased safety without compromising antitumor efficacy and overall treatment effect?

Bone marrow transplantation·2016

Aspergillus sinusitis in bone marrow transplant patients can be fatal. This case study shows a multidisciplinary approach including surgery, amphotericin B, and granulocyte transfusions can cure invasive Aspergillus flavus sinusitis.

Area of Science:

  • Medical Mycology
  • Hematology
  • Transplantation Immunology

Background:

  • Aspergillus sinusitis poses a significant lethal threat to immunocompromised patients, particularly those undergoing bone marrow transplantation.
  • Early diagnosis and intervention are critical for managing invasive fungal infections in this vulnerable population.

Observation:

  • A patient with refractory acute myelogenous leukemia developed Aspergillus flavus sinusitis prior to allogeneic bone marrow transplantation.
  • The sinusitis exacerbated during the neutropenic phase, necessitating aggressive management.

Findings:

  • A multidisciplinary approach combining Caldwell-Luc surgery, prolonged amphotericin B colloidal dispersion (ABCD) therapy (7 months), and granulocyte transfusions achieved a cure.
  • Granulocyte transfusions were crucial in the salvage setting, supporting the patient through the pre-engraftment period.

Related Experiment Videos

Implications:

  • Aggressive, multimodality treatment strategies can lead to successful outcomes for invasive aspergillus sinusitis in immunosuppressed patients.
  • Successful management of invasive fungal infections may not necessarily preclude allogeneic stem cell transplantation.