[Structure and function of influenza virus neuraminidase]

Crystallographic studies of neuraminidase and neuraminidase-sialic acid complexes enabled to design new potent antiviral drugs against influenza. In addition, recent advance in reverse genetics of influenza virus provides us a better understanding of interrelationship between structure and function of the neuraminidase. Progress in elucidating the relationship between structure and function will further contribute to the control of influenza.