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Intraerythrocytic 2,3-diphosphoglycerate concentration in hypertensive subjects before and following control by anti

H Kasparian1, K Konstantopoulos, S Tassiopoulos

  • 1First Department of Medicine, Athens University Medical School, Greece.

Panminerva Medica
|November 14, 1997
PubMed

Insights

Hypertension is linked to higher 2,3-diphosphoglycerate (2,3-DPG) levels, which normalize after effective drug therapy. This suggests 2,3-DPG may indicate tissue perfusion in hypertensive patients.

Area of Science:

  • Biochemistry
  • Cardiovascular Physiology
  • Hematology

Background:

  • Hypertension is a prevalent cardiovascular condition.
  • Altered red blood cell metabolism may occur in hypertension.
  • 2,3-diphosphoglycerate (2,3-DPG) influences hemoglobin-oxygen affinity.

Purpose of the Study:

  • To investigate the intraerythrocytic concentration of 2,3-diphosphoglycerate (2,3-DPG) in patients with hypertension.
  • To determine if 2,3-DPG levels change following antihypertensive drug therapy.
  • To explore the potential of 2,3-DPG as a marker for tissue perfusion in hypertension.

Main Methods:

  • Measured intraerythrocytic 2,3-diphosphoglycerate (2,3-DPG) concentration.
  • Included 24 normal controls and 24 hypertensive patients.
  • Measurements were taken before and after drug therapy for hypertension.

Main Results:

  • Hypertensive patients exhibited significantly higher 2,3-DPG levels compared to controls (14.96 mumol/g Hb vs 13.26 mumol/g Hb, p < 0.001).
  • Following successful drug therapy to control hypertension, 2,3-DPG levels in patients were no longer statistically different from controls.
  • These findings suggest a correlation between hypertension, 2,3-DPG levels, and the effectiveness of treatment.

Conclusions:

  • Elevated 2,3-DPG in hypertension might be related to reduced cardiac output and tissue perfusion.
  • Increased deoxygenated hemoglobin in venous blood could contribute to higher 2,3-DPG.
  • Measuring 2,3-diphosphoglycerate may serve as a valuable tool for assessing tissue perfusion in hypertensive individuals.
Abstract

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