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5-Hydroxytryptamine extraction by the lung

L H Cronau, M D Kerstein, S Mandel

Surgery, Gynecology & Obstetrics

|July 1, 1976

Summary

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The dog lung removes both serotonin and norepinephrine from blood, with serotonin uptake being greater. Imipramine drug dose-dependently inhibits this serotonin uptake in intact dogs.

Area of Science:

Pharmacology and Physiology
Cardiovascular Research

Background:

The pulmonary vasculature plays a role in removing vasoactive substances from the blood.
5-hydroxytryptamine (serotonin) and norepinephrine are key neurotransmitters with roles in various physiological processes.

Purpose of the Study:

To investigate the pulmonary extraction of 5-hydroxytryptamine and norepinephrine in dogs.
To compare these extraction levels to those found in humans.
To determine the effect of imipramine on 5-hydroxytryptamine uptake in the canine lung.

Main Methods:

Single-passage study design through the pulmonary vasculature of dogs.
Measurement of 5-hydroxytryptamine and norepinephrine concentrations in blood.
Administration of varying doses of imipramine to assess its inhibitory effect.

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Main Results:

Both 5-hydroxytryptamine and norepinephrine are significantly extracted from blood during pulmonary passage in dogs.
5-hydroxytryptamine extraction is more pronounced than norepinephrine extraction.
The extraction magnitudes in dogs closely resemble those previously observed in humans.
Imipramine demonstrated a dose-dependent inhibition of 5-hydroxytryptamine uptake by the lung.

Conclusions:

The canine pulmonary vasculature effectively removes both 5-hydroxytryptamine and norepinephrine.
Imipramine acts as an inhibitor of pulmonary 5-hydroxytryptamine uptake in dogs.
Findings suggest conserved mechanisms for vasoactive amine handling across species.