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Risperidone-induced neuroleptic malignant syndrome

I Bajjoka¹, T Patel, T O'Sullivan

¹Department of Pharmacy Practice, Wayne State University, Detroit, MI, USA.

Annals of Emergency Medicine

|November 14, 1997

Summary

This summary is machine-generated.

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Risperidone, an antipsychotic for schizophrenia, can rarely cause Neuroleptic Malignant Syndrome (NMS). This case highlights the risk in geriatric patients, emphasizing the need for clinical awareness.

Area of Science:

Pharmacology
Neurology
Geriatrics

Background:

Risperidone, an atypical antipsychotic, is prescribed for schizophrenia.
It was theorized to have a lower risk of dystonia and Neuroleptic Malignant Syndrome (NMS) due to its unique receptor binding profile.
This profile includes weaker anti-dopaminergic and stronger antiserotoninergic activity.

Observation:

A geriatric patient developed symptoms indicative of NMS after three weeks of risperidone treatment.
Clinical presentation included fever, altered mental status, tremor, and rigidity.
Laboratory results revealed elevated serum creatine phosphokinase, hypernatremia, and metabolic acidosis.

Findings:

The patient's signs and symptoms were consistent with Neuroleptic Malignant Syndrome (NMS).

Related Experiment Videos

This case adds to the limited reports of risperidone-induced NMS.

The development of NMS challenges the initial assumptions about risperidone's safety profile regarding this adverse effect.

Implications:

Healthcare providers must remain vigilant for NMS symptoms in patients receiving risperidone, particularly the elderly.
This case underscores the importance of monitoring for serious adverse drug reactions even with atypical antipsychotics.
Further research may be warranted to fully understand the risk factors and incidence of risperidone-induced NMS.