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Is fibrin glue useful in preventing dialysate leakage in children on CAPD? Preliminary results of a prospective

E Sojo1, L Bisigniano, A Turconi

  • 1Nephrology Department, Garrahan Hospital, Buenos Aires, Argentina.

Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis
|January 1, 1997
PubMed

Insights

Fibrin glue applied during catheter implantation may prevent dialysate leakage in children undergoing continuous ambulatory peritoneal dialysis (CAPD). This preliminary study found no leakage in the fibrin glue group, suggesting a potential preventative benefit.

Area of Science:

  • Pediatric Nephrology
  • Surgical Innovation

Background:

  • Continuous ambulatory peritoneal dialysis (CAPD) is associated with a higher risk of dialysate leakage in children compared to cycler dialysis.
  • Fibrin glue has been used for treating, but not preventing, dialysate leakage.

Purpose of the Study:

  • To evaluate the efficacy of fibrin glue as a preventative measure against dialysate leakage during peritoneal dialysis catheter implantation in children.

Main Methods:

  • A prospective study involving 20 catheter implantations in 19 pediatric patients.
  • Catheters were randomized to receive either fibrin glue application to the peritoneal cuff suture (treatment group) or no treatment (control group).

Main Results:

  • No instances of dialysate leakage were observed in the fibrin glue treatment group (n=10).
  • Dialysate leakage occurred in 4 patients within the control group (n=10), with 3 requiring early dialysis initiation.
  • No significant differences in patient age, time to first catheter use, or albumin levels were noted between groups.

Conclusions:

  • Preliminary data suggest that fibrin glue application at the time of peritoneal dialysis catheter implantation may be beneficial in preventing dialysate leakage in pediatric patients.
  • Further research and experience are needed to establish fibrin glue as a routine preventative method.

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