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An update on diseases of the pancreas in children
1Pediatric Gastroenterology and Nutrition Unit, Soroka Medical Center, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, Israel.
Insights
This review covers recent advances in pediatric pancreatic disorders, including hereditary pancreatitis genetics, acute pancreatitis risks, and rare genetic syndromes. It highlights novel causes and systemic associations like diabetes mellitus.
Area of Science:
- Pediatric Gastroenterology
- Genetics
- Endocrinology
Background:
- Pancreatic disorders in children represent a significant clinical challenge.
- Understanding recent advancements is crucial for improved diagnosis and management.
- Hereditary pancreatitis and acute pancreatitis are key areas of concern.
Purpose of the Study:
- To review recent developments in pediatric pancreatic disorders.
- To highlight genetic research in hereditary pancreatitis.
- To discuss acute pancreatitis, novel etiologies, and associated systemic conditions.
Main Methods:
- Literature review of recent publications on pediatric pancreatic disorders.
- Synthesis of information on genetic research, acute pancreatitis, and rare syndromes.
- Focus on novel etiologies and systemic manifestations.
Main Results:
- Recent genetic research has advanced the understanding of hereditary pancreatitis.
- Acute pancreatitis in children carries significant morbidity and mortality risks.
- Novel etiologies and associations with conditions like diabetes mellitus have been identified.
Conclusions:
- Continued research into pediatric pancreatic disorders is essential.
- Early identification of genetic factors and novel etiologies can improve outcomes.
- Recognizing systemic associations is vital for comprehensive patient care.
Abstract:
The aim of this review is to describe recent developments in the field of pancreatic disorders in children. First, recent developments in the genetic research of hereditary pancreatitis are discussed. Subsequently, several issues of acute pancreatitis are presented. These include a description of the potential hazardous morbidity and mortality of this disorder in children. In addition, various novel etiologies that have been described lately in the medical literature are illustrated. Next, this paper discusses two examples of pancreatic disorders associated with systemic manifestations, i.e., ganglioneuromatosis and diabetes mellitus. Finally, a few rare genetic syndromes with pancreatic involvement are touched upon, an association that is not very well recognized. Cystic fibrosis is not covered.