Related Experiment Video
Updated: Aug 7, 2026

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
Published on: April 28, 2016
5-HT2C receptor activation decreases appetite and body weight in obese subjects
P A Sargent1, A L Sharpley, C Williams
1University Departement of Psychiatry, Littlemore Hospital, Oxford, UK.
Abstract:
We studied the effect of 2 weeks administration of the 5-HT2C receptor agonist, m-chlorophenylpiperazine (mCPP), on appetite and body weight in 18 moderately obese subjects in a double-blind, placebo-controlled trial, mCPP caused a small but significant (0.75 kg) reduction in body weight and in subjective ratings of hunger. Plasma prolactin was significantly elevated by the final dose of mCPP. Our data suggest that during 2 weeks treatment in humans, mCPP may continue to activate brain 5-HT2C receptors, and that this effect is associated with decreases in appetite and body weight.
More Related Videos
Related Concept Videos
Hormonal Regulation
GPCRs Regulate Adenylyl Cylase Activity
Two...
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
Regulation of Food Intake
Obesity
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

