Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Delayed xenograft rejection

W W Hancock1

  • 1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

World Journal of Surgery
|November 15, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Abstracts of presentations to the Annual Meetings of the Canadian Society of Colon and Rectal Surgeons Canadian Association of General Surgeons Canadian Association of Thoracic Surgeons: Canadian Surgery Forum, London, Ont., Sept. 19 to 22, 2002.

Canadian journal of surgery. Journal canadien de chirurgie·2023
Same author

Editorial: Mechanisms guarding the genome.

Frontiers in cell and developmental biology·2022
Same author

Histone/protein deacetylase inhibitor therapy for enhancement of Foxp3+ T-regulatory cell function posttransplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2018
Same author

Class-specific histone/protein deacetylase inhibition protects against renal ischemia reperfusion injury and fibrosis formation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

Blunted expression of miR-199a-5p in regulatory T cells of patients with chronic obstructive pulmonary disease compared to unaffected smokers.

Clinical and experimental immunology·2014
Same author

Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells.

Mucosal immunology·2014
Same journal

Feasibility of Post-Operative Telehealth for Pediatric Surgical Patients in Malawi-A Mixed Methods Analysis.

World journal of surgery·2026
Same journal

Surgical Infrastructure and Workforce Readiness in Rwanda's District and Level 2 Teaching Hospitals: A Nationwide Facility-Based Survey.

World journal of surgery·2026
Same journal

From General Preparedness to Injury-Pattern-Specific Trauma Resource Planning.

World journal of surgery·2026
Same journal

Prevalence and Outcomes of Thrombocytopenia at ICU Admission Among Critically Ill Patients in a Resource-Limited Setting.

World journal of surgery·2026
Same journal

Transition of Care From Pediatric to Adult Services for Patients With Anorectal Malformations: A Qualitative Study.

World journal of surgery·2026
Same journal

Analysis of Intraoperative Complications and Outcomes Associated With Obesity During Elective Laparoscopic Cholecystectomy.

World journal of surgery·2026
See all related articles

Delayed xenograft rejection (DXR) is a major hurdle in organ transplantation, characterized by innate immune responses and molecular incompatibilities. Understanding DXR mechanisms is crucial for advancing xenotransplantation therapies.

Area of Science:

  • Transplantation Immunology
  • Genetic Engineering
  • Immunology

Background:

  • Hyperacute rejection (HAR) is overcome by genetic engineering, but clinical xenotransplantation faces further immunologic barriers.
  • Delayed xenograft rejection (DXR) is a subsequent rejection phase occurring days after transplantation, even when HAR is prevented.

Purpose of the Study:

  • To describe the features of delayed xenograft rejection (DXR).
  • To elucidate the mechanisms underlying DXR.
  • To identify challenges and future directions for clinical xenotransplantation.

Main Methods:

  • Serial histological studies of xenografts undergoing DXR.
  • Analysis of immune cell infiltration (macrophages, NK cells) and microvascular events (platelet aggregation, fibrin deposition).

Related Experiment Videos

  • Assessment of endothelial activation and T cell-independent pathways.

    • Main Results:

    • DXR involves progressive infiltration by activated macrophages and NK cells.
    • Microvascular thrombosis, including platelet aggregation and fibrin deposition, is observed.
    • Endothelial activation occurs, and DXR is T cell-independent and can occur without xenoreactive antibodies.
    • DXR is resistant to standard immunosuppression, requiring toxic regimens.

    Conclusions:

    • DXR arises from innate host defense activation and regulatory failure due to molecular incompatibilities.
    • DXR presents a significant barrier to clinical xenotransplantation, resistant to current immunosuppression.
    • Further understanding of DXR mechanisms is essential for developing effective genetic engineering strategies for future xenotransplantation.