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Novel carbocyclic nucleosides containing a cyclopentyl ring. Adenosine and uridine analogues
1Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago, Spain.
Archiv Der Pharmazie
|August 1, 1997
Abstract:
cis-3-Aminomethylcyclopentylmethanol (4) was used as a precursor in the synthesis of carbocyclic nucleosides containing adenine, hypoxanthine, 8-azahypoxanthine, uracil, and 5-iodouracil bases. None of these compounds had appreciable activity against eighteen viruses in the concentration ranges tested. Two of them showed a weak cytostatic activity against three tumor lines.