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Synthesis and antimicrobial testing of novel oxadiazolylbenzimidazole derivatives
N S Habib1, R Soliman, F A Ashour
1Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Egypt.
Die Pharmazie
|November 15, 1997
Abstract:
Three novel series of oxadiazolylbenzimidazole derivatives have been prepared, namely 1-[(2-alkylthio or aralkylthio-1,3,4-oxadiazol-5-yl)methyl]-2-alkyl-1 H-benzimidazoles 3a-f; 1-[(3-substituted aminomethyl-2-thioxo-2,3-dihydro-1,3,4-oxadiazol-5-yl)methyl ]-2-alkyl-1 H-benzimidazoles 4a-f and 1-[(2-substituted amino-1,3,4-oxidiazol-5-yl)methyl]-2-alkyl-1 H-benzimidazoles 6a-j. The antimicrobial testing of the prepared compounds was performed, some of them showed week activity.