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Expression of CD34 in glomus tumors
1Department of Orthopaedic Surgery, Tohoku University School of Medicine, Japan.
The Tohoku Journal of Experimental Medicine
|July 1, 1997
Summary
Glomus tumors express smooth muscle actin, with some also showing desmin. These cells are distinct from endothelial cells, which express Factor VIII and Ulex europaeus agglutinin-I.
Area of Science:
- Oncology
- Pathology
- Cell Biology
Background:
- Glomus tumors are rare neoplasms originating from glomus bodies.
- Accurate characterization is crucial for diagnosis and understanding tumor biology.
Purpose of the Study:
- To immunohistochemically characterize glomus tumors.
- To differentiate glomus tumor cells from endothelial cells.
Main Methods:
- Immunohistochemical staining for smooth muscle actin, desmin, Ulex europaeus agglutinin-I, Factor VIII-related antigen, and CD34.
- Analysis of staining patterns in glomus tumor tissues.
Main Results:
- All glomus tumor cells were positive for smooth muscle actin.
- Half of the cases showed weak desmin expression in tumor cells.
- Endothelial cells were positive for Ulex europaeus agglutinin-I and Factor VIII-related antigen, while tumor cells were negative.
- CD34 expression was observed in tumor cells and endothelial cells in five cases.
Conclusions:
- Glomus tumor cells exhibit smooth muscle differentiation.
- Immunohistochemistry aids in distinguishing glomus tumors from vascular lesions.
- Smooth muscle actin is a reliable marker for glomus tumor cells.