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Updated: Feb 17, 2026

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals
Published on: September 20, 2021
Gastritis secondary to herpes simplex virus
1Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas, USA.
Herpes simplex virus gastritis is a rare gastric infection. Routine biopsies and viral cultures are crucial for diagnosing this condition in immunocompromised patients with stomach issues.
Area of Science:
- Gastroenterology
- Virology
- Infectious Diseases
Background:
- Gastric infection with herpes simplex virus (HSV) is exceptionally rare.
- Previous diagnoses relied solely on histological findings due to difficulties in viral culture.
Observation:
- Presents two cases of culture-positive HSV gastritis.
- Highlights the diagnostic challenges in immunocompromised individuals presenting with dyspeptic symptoms.
Findings:
- Demonstrates successful viral culture for HSV in gastric biopsies.
- Confirms HSV gastritis as a treatable cause of dyspepsia in the immunocompromised.
Implications:
- Underscores the importance of considering HSV in the differential diagnosis of gastritis.
- Recommends routine gastric biopsies and viral cultures for immunocompromised patients with unexplained dyspeptic symptoms.
- Advances understanding of rare viral infections affecting the upper gastrointestinal tract.
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