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Related Experiment Videos

Pubertal changes in insulin secretion and peripheral insulin sensitivity

N Potau1, L Ibañez, S Riqué

  • 1Hormonal Laboratory, Hospital Materno-Infantil Vall d'Hebron, Autonomous University, Barcelona, Spain.

Hormone Research
|January 1, 1997
PubMed
Summary

Puberty alters insulin dynamics. This study shows increased insulin secretion and insulin resistance starting at Tanner stage II in girls, highlighting a critical window for metabolic changes.

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Area of Science:

  • Endocrinology
  • Pediatric Metabolism
  • Human Physiology

Background:

  • Pubertal development involves significant hormonal changes affecting metabolic processes.
  • Understanding insulin secretion and sensitivity during puberty is crucial for identifying metabolic health risks.
  • Previous research indicates potential shifts in glucose metabolism during adolescence.

Purpose of the Study:

  • To evaluate insulin secretion and insulin sensitivity in relation to Tanner pubertal stages in normal girls.
  • To characterize changes in metabolic parameters during pubertal development using a standardized oral glucose tolerance test.
  • To establish a simple and reliable method for assessing insulin dynamics in pediatric populations.

Main Methods:

  • A cohort of 73 normal girls was divided into four Tanner pubertal stage groups.

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  • Standard oral glucose tolerance tests were performed to measure mean blood glucose (MBG), mean serum insulin (MSI), and glucose uptake.
  • Insulin sensitivity index (SI) was calculated, and steroid/IGF levels were determined to assess pubertal development.

    • Main Results:

    • Mean blood glucose remained consistent across all Tanner stages.
    • Mean serum insulin increased significantly at Tanner stage II and remained elevated, with lower levels in Tanner stage I.
    • Insulin sensitivity (SI) was significantly lower in later pubertal stages (III-V) compared to early stages (I-II).

    Conclusions:

    • Insulin secretion and sensitivity are significantly influenced by pubertal stage.
    • An insulin-resistant state emerges during puberty, coinciding with Tanner stage II.
    • The utilized mathematical approach offers a simple, reliable method for studying insulin dynamics in children and adolescents.