Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Skeletal complications of malignancy

R E Coleman1

  • 1Yorkshire Cancer Research Campaign, Department of Clinical Oncology, Weston Park Hospital, Sheffield, United Kingdom.

Cancer
|November 15, 1997
PubMed
Summary

Metastatic bone disease, common in breast and prostate cancers, causes pain and fractures. Prognostic factors like tumor grade and receptor status help guide bisphosphonate treatment for advanced cancer patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bone resorption predicts for skeletal complications in metastatic bone disease.

British journal of cancer·2003
Same author

Chemotherapy, erythropoietin and bloodless surgery in a Jehovah's Witness.

Clinical oncology (Royal College of Radiologists (Great Britain))·2003
Same author

Light, carbon dioxide, and octenol-baited mosquito trap and host-seeking activity evaluations for mosquitoes in a malarious area of the Republic of Korea.

Journal of the American Mosquito Control Association·2003
Same author

The use of zoledronic acid in the management of metastatic bone disease and hypercalcaemia.

Palliative medicine·2003
Same author

Molecular serotyping of dengue viruses in field-caught Aedes mosquitos by in-house RNA extraction/RT-PCR reagent kits.

The Southeast Asian journal of tropical medicine and public health·2003
Same author

Linkages between facial expressions of anger and transient myocardial ischemia in men with coronary artery disease.

Emotion (Washington, D.C.)·2003

Area of Science:

  • Oncology
  • Skeletal Metastasis

Background:

  • The skeleton is the most frequent site of cancer metastasis.
  • Breast carcinoma is the most prevalent malignancy, leading to significant morbidity from bone involvement.

Purpose of the Study:

  • To review the clinical significance of bone metastases.
  • To discuss complications such as pain and hypercalcemia.
  • To outline prognostic factors for survival in patients with skeletal metastases.

Main Methods:

  • Literature review of metastatic bone disease.
  • Analysis of prognostic factors for breast, prostate, and multiple myeloma.
  • Discussion of treatment implications, including bisphosphonates.

Main Results:

  • Bone pain is the most common complication, potentially linked to bone resorption rates.
  • Hypercalcemia affects 5-10% of advanced cancer patients, particularly those with breast carcinoma.
  • Prognostic factors vary by cancer type, influencing survival and treatment strategies.

Conclusions:

  • Metastatic bone disease significantly impacts quality of life and survival.
  • Understanding prognostic factors is crucial for personalized treatment planning.
  • Bisphosphonates represent a key therapeutic option for managing advanced cancer with bone involvement.

Related Experiment Videos