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2-Aminonicotinic acid

A J Dobson1, R E Gerkin

  • 1Department of Chemistry, Ohio State University, Columbus 43210, USA.

Acta Crystallographica. Section C, Crystal Structure Communications
|November 18, 1997
PubMed
Summary
This summary is machine-generated.

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This study details the crystal structure of 2-aminonicotinic acid, revealing its zwitterionic form. Molecular interactions, including hydrogen bonds, dictate its crystal packing and chain formation.

Area of Science:

  • Crystallography
  • Chemical Physics
  • Materials Science

Background:

  • 2-Aminonicotinic acid is an organic compound with potential applications in various chemical fields.
  • Understanding its solid-state structure is crucial for predicting its physical and chemical properties.

Purpose of the Study:

  • To determine the precise crystal structure of 2-aminonicotinic acid.
  • To elucidate the intermolecular interactions governing its solid-state arrangement.

Main Methods:

  • Single-crystal X-ray diffraction was employed to analyze the crystal structure.
  • Analysis of hydrogen bonding networks and dihedral angles provided insights into molecular interactions.

Main Results:

  • 2-Aminonicotinic acid crystallizes in the P2(1)/c space group as a zwitterion.

Related Experiment Videos

  • Intermolecular N--H...O hydrogen bonds form two sets of zigzag chains along the b axis.
  • C--H...O interactions further crosslink these chains, with a dihedral angle of 9.77 degrees between adjacent molecules.

    • Conclusions:

    • The crystal structure is stabilized by a combination of intermolecular N--H...O and C--H...O hydrogen bonds.
    • The observed packing arrangement influences the compound's physical characteristics and potential reactivity.